IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).
Alexandre Stouffs, Sonya C Chapman, Francesca Fardo, Bernd Genser, Marcus Goetz, Anna V Kostenko, Caterina Leone, Thomas Li, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart, Ombretta Caspani, Irene Tracey, Iñaki F Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer, Hatice Tankisi, Nanna B Finnerup, Keith G Phillips, Rolf-Detlef Treede, Andrea Truini, Zahra Nochi, Hossein Pia, Petra Bloms-Funke, Irmgard Boesl
Trials 2022;23(1):163