Quality of life and functional outcomes with tapentadol prolonged release in chronic musculoskeletal pain: analysis.

Cesar Margarit Ferri, Silvia Natoli, Paz Sanz-Ayan, Alberto Magni, Carlos Guerrero, Argelia Lara-Solares, Hiltrud Liedgens, Guido Thömmes, Ravi Karra

Journal: Pain management 2021;11(2):173-187

PMID: 33241725

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Abstract

To investigate quality of life (QOL) and functionality changes in chronic pain during tapentadol prolonged release (PR) treatment. analysis of data from three Phase III trials in patients with osteoarthritis knee pain or low back pain. QOL and functionality changes were assessed by SF-36 scores. All SF-36 subdomain scores improved progressively to week 3 of tapentadol titration and were sustained during 12-week maintenance treatment. Improvements in SF-36 scores were similar between tapentadol dose groups (e.g., 200 to <300 mg vs ≥500 mg), with no greater effect from higher doses. QOL and functionality improvements were consistently greater with tapentadol PR than oxycodone controlled release. Tapentadol PR provides consistent, clinically relevant improvements in QOL and functionality in chronic pain.

Address: Hospital General Universitario de Alicante, Alicante, 03010, Spain.; University of Rome Tor Vergata, Department of Clinical Science & Translational Medicine & Unit of Pain Therapy, Polyclinic of Tor Vergata, Rome, 00133, Italy.; Hospital Universitario 12 de Octubre; Department of Rehabilitation, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Italian College of General Practitioners & Primary Care, Florence, 50141, Italy.; Hospital Universitario Fundación Santa Fe, Bogotá 110121, Universidad de los Andes, Colombia.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico.; Global Market Access, Grünenthal GmbH, Aachen, 52099, Germany.; R&D - Development - Data Sciences, Grünenthal GmbH, Aachen, 52099, Germany.; Global Medical Affairs, Grünenthal GmbH, Aachen, 52099, Germany.

DOI: 10.2217/pmt-2020-0084

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Full Text Sources:

https://www.tandfonline.com/doi/10.2217/pmt-2020-0...

Medical:

https://medlineplus.gov/chronicpain.html

Other Literature Sources:

https://scite.ai/reports/33241725

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-PGR-1

MeSH Terms: Adult, Aged, Analgesics, Opioid, Chronic Pain, Delayed-Action Preparations, Double-Blind Method, Female, Functional Status, Humans, Low Back Pain, Male, Middle Aged, Musculoskeletal Pain, Osteoarthritis, Outcome Assessment, Health Care, Quality of Life, Tapentadol