Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
F Chen, W A M Elgaher, M Winterhoff, K Büssow, F H Waqas, E Graner, Y Pires-Afonso, L Casares Perez, L de la Vega, N Sahini, L Czichon, W Zobl, T Zillinger, M Shehata, S Pleschka, H Bähre, C Falk, A Michelucci, S Schuchardt, W Blankenfeldt, A K H Hirsch, F Pessler
Nature metabolism 2022;4(5):534-546