Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Alexander C Ford, Matthew Chaddock, Delia P Muir, Daniel Howdon, Amy Herbert, Suzanne Hartley, Elspeth A Guthrie, Catherine Fernandez, Deborah Cooper, Heather Cook, Taposhi Nath, Felicity L Bishop, Gina Bianco, Robbie Foy, Matthew J Ridd, Pei-Loo Ow, Sarah L Alderson, Alexandra Wright-Hughes, Sonia Newman, Hazel A Everitt, Amanda J Farrin, Ruth Thornton, Emma J Teasdale, Christopher A Taylor, Thomas Smith
Lancet (London, England) 2023;402(10414):1773-1785