Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline.

S M Taibjee, P Ramani, R Brown, C Moss

Journal: Archives of disease in childhood 2005;90(8):871-2

PMID: 16040888

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Abstract

There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder. The pathogenesis of DCM in RDEB remains uncertain, although dietary deficiency of selenium and carnitine have been implicated. A 6 year old girl with RDEB who died of DCM is reported; attention is drawn to the possible role of two potentially cardiotoxic drugs, amitriptyline and cisapride.

Address: Department of Dermatology, Birmingham Children's Hospital, UK. [email protected]

DOI: 10.1136/adc.2004.068775

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MeSH Terms: Amitriptyline, Antidepressive Agents, Tricyclic, Cardiomyopathy, Dilated, Cisapride, Epidermolysis Bullosa, Fatal Outcome, Female, Humans, Infant, Serotonin Receptor Agonists