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Susana Banerjee, Bora Gurel, Ruth Riisnaes, Florence Raynaud, Ruth Ruddle, Martin Little, Ionut-Gabriel Funingana, Andrea Biondo, Alvaro Ingles Garces, Joo Ern Ang, Vasiliki Michalarea, Sue Chua, Anna Minchom, Udai Banerji, Bristi Basu, Natalie Cook, Emma Hall, Robert Jones, Johann de Bono, Juanita Lopez, Ed Ainscow, Stuart McIntosh, Ben Jenkins, Alison Turner, Anna Zachariou, Mona Parmar, Toby Prout, Joanna C Porter, Nina Tunariu

Clinical cancer research : an official journal of the American Association for Cancer Research 2022;28(21):4634-4641

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Results for ""Thymidylate Synthase""[mesh_terms]

Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.

High-level QM/MM calculations support the concerted mechanism for Michael addition and covalent complex formation in thymidylate synthase.

5,10-Methylene-5,6,7,8-tetrahydrofolate conformational transitions upon binding to thymidylate synthase: molecular mechanics and continuum solvent studies.

Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases.

The origin and diversification of eukaryotes: problems with molecular phylogenetics and molecular clock estimation.

Bacterial origins of thymidylate metabolism in Asgard archaea and Eukarya.

Regulation of thymidylate synthase: an approach to overcome 5-FU resistance in colorectal cancer.

Biochemical pharmacology of pemetrexed.

QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase.

Mechanisms and inhibition of uracil methylating enzymes.

A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase.

Recent Design and Structure-Activity Relationship Studies on the Modifications of DHFR Inhibitors as Anticancer Agents.

Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS).

A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer.

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""Thymidylate Synthase""[mesh_terms]