Results for
""Receptor, Melanocortin, Type 4""[mesh_terms]

Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.

Nicolas A Heyder, Gunnar Kleinau, David Speck, Andrea Schmidt, Sarah Paisdzior, Michal Szczepek, Brian Bauer, Anja Koch, Monique Gallandi, Dennis Kwiatkowski, Jörg Bürger, Thorsten Mielke, Annette G Beck-Sickinger, Peter W Hildebrand, Christian M T Spahn, Daniel Hilger, Magdalena Schacherl, Heike Biebermann, Tarek Hilal, Peter Kühnen, Brian K Kobilka, Patrick Scheerer

Cell research 2022;31(11):1176-1189

Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway-Associated Disease: A Roundtable Summary.

Beatrice Dubern, Peter Kühnen, Martin Wabitsch, Anthony P Goldstone, Christian L Roth, Steven B Heymsfield, Karine Clément, Andrea M Haqq, Jack A Yanovski, Jesse Richards, Erica L T van den Akker

Current obesity reports 2025;14(1):13

Melanocortin-4 receptor complexity in energy homeostasis,obesity and drug development strategies.

Munazza Tamkeen Fatima, Ikhlak Ahmed, Khalid Adnan Fakhro, Ammira Sarah Al-Shabeeb Akil

Diabetes, obesity & metabolism 2022;24(4):583-598

Hyperphagia in Bardet-Biedl syndrome: Pathophysiology, burden, and management.

Metin Cetiner, Jennifer Miller, Miriam Zacchia, Diana Valverde, Ashley H Shoemaker, Hélène Dollfus, Andrea M Haqq, Philip L Beales

Obesity reviews : an official journal of the International Association for the Study of Obesity 2025;26(7):e13915

Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period.

Guojun Yuan, Andrea M Haqq, Wendy K Chung, Hélène Dollfus, Robert M Haws, Gabriel Á Martos-Moreno, Christine Poitou, Jack A Yanovski, Robert S Mittleman, Elizabeth Forsythe, Karine Clément, Jesús Argente

The lancet. Diabetes & endocrinology 2022;10(12):859-868

Association of MC4R rs17782313 Genotype With Energy Intake and Appetite: A Systematic Review and Meta-analysis.

Rocio de la Iglesia, Cristina Álvarez-Martín, Francisco Félix Caballero, Elena Alonso-Aperte

Nutrition reviews 2025;83(3):e931-e946

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway.

Varvara Kanti, Lia Puder, Irina Jahnke, Philipp Maximilian Krabusch, Jan Kottner, Annika Vogt, Claudia Richter, Annette Andruck, Lara Lechner, Christine Poitou, Heiko Krude, Keith Gottesdiener, Karine Clément, Ismaa Sadaf Farooqi, Susanna Wiegand, Peter Kühnen, Ulrike Blume-Peytavi

Skin pharmacology and physiology 2022;34(6):307-316

Improving the diagnosis of hyperphagia in melanocortin-4 receptor pathway diseases.

Beatrice Dubern, Jennifer L Miller, Martin Wabitsch, Anthony P Goldstone, M Jennifer Abuzzahab, Steven B Heymsfield, Andrea M Haqq, Jack A Yanovski, Jesse Richards

Obesity (Silver Spring, Md.) 2025;33(7):1217-1231

Candidate genes for obesity--how might they interact with environment and diet?

I Sadaf Farooqi

Advances in experimental medicine and biology 2005;569():33-4

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery.

Joshua S Bloom, Henry Chan, Dean R Artis, Conor J Howard, Nathan S Abell, Beatriz A Osuna, Eric M Jones, Leon Y Chan, Jonathan B Asfaha, Aaron R Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A Uribe, Sriram Kosuri, Diane E Dickel, Nathan B Lubock

eLife 2025;13():

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.

Lara Lechner, Robert Opitz, Matt J Silver, Philipp M Krabusch, Andrew M Prentice, Martha S Field, Harald Stachelscheid, Elsa Leitão, Christopher Schröder, Valeria Fernandez Vallone, Bernhard Horsthemke, Karl-Heinz Jöckel, Börge Schmidt, Markus M Nöthen, Per Hoffmann, Stefan Herms, Patrick W Kleyn, Matthias Megges, Ulrike Blume-Peytavi, Katja Weiss, Knut Mai, Oliver Blankenstein, Benedikt Obermayer, Susanna Wiegand, Peter Kühnen

Science translational medicine 2023;15(705):eadg1659

Monoallelic pathogenic variants in LEPR do not cause obesity.

Audrey Leloire, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Amélie Bonnefond, Philippe Froguel, Mehdi Derhourhi, Lauriane Le Collen, Bénédicte Toussaint, Emmanuel Vaillant, Hélène Loiselle, Jérôme Delplanque, Emma Henriques, Emmanuel Buse Falay

American journal of human genetics 2024;111(12):2668-2674

Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes.

Christine Poitou, Lia Puder, Beatrice Dubern, Philipp Krabusch, Laurent Genser, Susanna Wiegand, Hélène Verkindt, Arvid Köhn, Reiner Jumpertz von Schwartzenberg, Christa Flück, François Pattou, Martine Laville, Peter Kühnen, Karine Clément

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2021;17(8):1449-1456

Setmelanotide in patients aged 2-5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial.

Hak-Myung Lee, Charles F Verge, Ilene Fennoy, Megan M Kelsey, I Sadaf Farooqi, Jesús Argente, Uzoma Okorie, Casey Cokkinias, Cecilia Scimia

The lancet. Diabetes & endocrinology 2024;13(1):29-37