Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection.
James F Cummings, Michele D Spring, Robert J Schwenk, Christian F Ockenhouse, Kent E Kester, Mark E Polhemus, Douglas S Walsh, In-Kyu Yoon, Christine Prosperi, Laure Y Juompan, David E Lanar, Urszula Krzych, B Ted Hall, Lisa A Ware, V Ann Stewart, Jack Williams, Megan Dowler, Robin K Nielsen, Collette J Hillier, Birgitte K Giersing, Filip Dubovsky, Elissa Malkin, Kathryn Tucker, Marie-Claude Dubois, Joe D Cohen, W Ripley Ballou, D Gray Heppner
Vaccine 2010;28(31):5135-44