Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.
Marie Nachon, Jacob D Durrant, Sabine Ottilie, Edgar Vigil, Kenneth E Allen, Felicia Gunawan, Maxim Kostylev, Kiersten A Henderson, Jennifer Yang, Jake Schenken, Gregory M LaMonte, Micah J Manary, Ayako Murao, Gregory M Goldgof, Rebecca Murray, Maximo Prescott, Case W McNamara, Carolyn W Slayman, Rommie E Amaro, Yo Suzuki, Elizabeth A Winzeler
Scientific reports 2018;6():27806