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Seema U Nayak, J McLeod Griffiss, Jeffrey Blumer, Mary Ann O'Riordan, Wesley Gray, Robin McKenzie, Robert A Jurao, Amanda T An, Melissa Le, Stacie J Bell, Urs A Ochsner, Thale C Jarvis, Nebojsa Janjic, Jonathan M Zenilman

Antimicrobial agents and chemotherapy 2018;61(8):e02760-16

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Enzymatic conversion of cytidine to lysidine in anticodon of bacterial isoleucyl-tRNA--an alternative way of RNA editing.

Henri Grosjean, Glenn R Björk

Trends in biochemical sciences 2004;29(4):165-8

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Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors.

Nagakumar Bharatham, Kavitha Bharatham, Keun Woo Lee

Journal of molecular graphics & modelling 2007;25(6):813-23

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Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.

Blaire Osborn, Nebojsa Janjic, Shahida Baqar, Thale C Jarvis, Urs A Ochsner, Stacie J Bell, Ronald J Evans, Catherine A Lozupone, Keith Hazleton, Jacques Ravel, Wael El-Amin, George A Saviolakis, Jared Schettler, Hal Galbraith, Barbara K Lomeli

Antimicrobial agents and chemotherapy 2020;64(1):e01395-19

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Results for ""Methionine-tRNA Ligase""[mesh_terms]

Bacterial Hydrazine Biosynthetic Pathways Featuring Cupin/Methionyl tRNA Synthetase-like Enzymes.

Probing interactions of aminoacyl-adenylate with methionyl-tRNA synthetase through site-directed mutagenesis and free energy calculation.

Computational Insight into Substrate-Induced Conformational Changes in Methionyl-tRNA Synthetase of Mycobacterium Tuberculosis.

Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments.

Novel methionyl-tRNA synthetase gene variants/phenotypes in interstitial lung and liver disease: A case report and review of literature.

Deep phenotyping of MARS1 (interstitial lung and liver disease) and LARS1 (infantile liver failure syndrome 1) recessive multisystemic disease using Human Phenotype Ontology annotation: Overlap and differences. Case report and review of literature.

The role of genomics in antimicrobial discovery.

Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power.

A study of communication pathways in methionyl- tRNA synthetase by molecular dynamics simulations and structure network analysis.

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.

Enzymatic conversion of cytidine to lysidine in anticodon of bacterial isoleucyl-tRNA--an alternative way of RNA editing.

Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors.

Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.

Results for
""Methionine-tRNA Ligase""[mesh_terms]