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Results for
""HIV Protease""[mesh_terms]

437 Results

Searching titles within these results

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants.

Shin-Ichiro Hattori, Arun K Ghosh, Manabu Aoki, Kazuya Hasegawa, Prasanth R Nyalapatla, Kalapala Venkateswara Rao, Haydar Bulut, Hironori Hayashi, Hiroaki Mitsuya

Antimicrobial agents and chemotherapy 2020;63(6):e02635-18

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Abstract

Virtual Screening for HIV Protease Inhibitors Using a Novel Database Filtering Procedure.

Kalev Takkis, Alfonso T García-Sosa, Sulev Sild

Molecular informatics 2018;34(6-7):485-92

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Abstract

Effects of plant extracts on HIV-1 protease.

Jaime Ribeiro Filho, Heloina de Sousa Falcão, Leônia Maria Batista, José Maria Barbosa Filho, Márcia Regina Piuvezam

Current HIV research 2011;8(7):531-44

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Abstract

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.

Hironori Hayashi, Nobutoki Takamune, Takashi Nirasawa, Manabu Aoki, Yoshihiko Morishita, Debananda Das, Yasuhiro Koh, Arun K Ghosh, Shogo Misumi, Hiroaki Mitsuya

Proceedings of the National Academy of Sciences of the United States of America 2014;111(33):12234-9

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Machine learning-based prediction of bioactivity in HIV-1 protease: insights from electron density analysis.

Shivananda Kandagalla, Maria Grishina, Vladislav Naumovich

Future medicinal chemistry 2025;16(24):2599-2607

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Abstract

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors .

Hiroaki Mitsuya, Arun K Ghosh, Cuthbert D Martyr, Kazuya Hasegawa, Hironori Hayashi, Pedro Miguel Salcedo-Gómez, Ravikiran S Yedidi, Masayuki Amano

Antimicrobial agents and chemotherapy 2022;66(2):e0171521

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Abstract

Interchain hydrophobic clustering promotes rigidity in HIV-1 protease flap dynamics: new insights from molecular dynamics.

Biswa Ranjan Meher, Mattaparthi Venkata Satish Kumar, Pradipta Bandyopadhyay

Journal of biomolecular structure & dynamics 2014;32(6):899-915

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Abstract

Linear and cyclic glycopeptide as HIV protease inhibitors.

Sachin A Pawar, Amit M Jabgunde, Glenn E M Maguire, Hendrik G Kruger, Yasien Sayed, Mahmoud E S Soliman, Dilip D Dhavale, Thavendran Govender

European journal of medicinal chemistry 2013;60():144-54

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Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.

Yunfeng Tie, Andrey Y Kovalevsky, Peter Boross, Yuan-Fang Wang, Arun K Ghosh, Jozsef Tozser, Robert W Harrison, Irene T Weber

Proteins 2007;67(1):232-42

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Abstract

Computational mutation scanning and drug resistance mechanisms of HIV-1 protease inhibitors.

Guang-Fu Yang, Chang-Guo Zhan, Ge-Fei Hao

The journal of physical chemistry. B 2010;114(29):9663-76

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Abstract

A study of the interaction between HIV-1 protease and C 2-symmetric inhibitors by computational methods.

Shuhua Shi, Guodong Hu, Xiumei Zhang, Jihua Wang

Journal of molecular modeling 2015;20(8):2369

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The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints.

Shaimaa M Ahmed, Glenn E M Maguire, Hendrik G Kruger, Thirumala Govender

Chemical biology & drug design 2015;83(4):472-81

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Abstract

Protease inhibition in African subtypes of HIV-1.

Adrián Velázquez-Campoy, Sonia Vega, Erin Fleming, Usman Bacha, Yasien Sayed, Heini W Dirr, Ernesto Freire

AIDS reviews 2004;5(3):165-71

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Machine learning-guided design of potent darunavir analogs targeting HIV-1 proteases: A computational approach for antiretroviral drug discovery.

Kowit Hengphasatporn, Chanat Aonbangkhen, Tanatorn Khotavivattana, Fahsai Nakarin, Jiramet Kinchagawat, Kajjana Boonpalit, Hathaichanok Chuntakaruk, Thanyada Rungrotmongkol, Sarana Nutanong, Yasuteru Shigeta, Supot Hannongbua

Journal of computational chemistry 2024;45(13):953-968

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Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

Hiroaki Mitsuya, Irene T Weber, Masayuki Amano, Manabu Aoki, Arun K Ghosh, W Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang

ChemMedChem 2017;12(23):1942-1952

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Results: 1 – 15 / 437

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Results for ""HIV Protease""[mesh_terms]

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants.

Virtual Screening for HIV Protease Inhibitors Using a Novel Database Filtering Procedure.

Effects of plant extracts on HIV-1 protease.

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.

Machine learning-based prediction of bioactivity in HIV-1 protease: insights from electron density analysis.

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors .

Interchain hydrophobic clustering promotes rigidity in HIV-1 protease flap dynamics: new insights from molecular dynamics.

Linear and cyclic glycopeptide as HIV protease inhibitors.

Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.

Computational mutation scanning and drug resistance mechanisms of HIV-1 protease inhibitors.

A study of the interaction between HIV-1 protease and C 2-symmetric inhibitors by computational methods.

The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints.

Protease inhibition in African subtypes of HIV-1.

Machine learning-guided design of potent darunavir analogs targeting HIV-1 proteases: A computational approach for antiretroviral drug discovery.

Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

Results for
""HIV Protease""[mesh_terms]