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Results for
""Drug Inverse Agonism""[mesh_terms]

18 Results

Searching titles within these results

Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.

Meng Cui, Nicholas R Fragola, Raymond G Booth, Munmun Mukherjee, Brittany M Brems

ACS chemical neuroscience 2023;14(10):1884-1895

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Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance.

Stephan Hjorth, Johan Gabrielsson

Pharmacological reviews 2023;75(3):416-462

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A Randomized, Controlled Trial of Efficacy and Safety of Cannabidiol in Idiopathic and Diabetic Gastroparesis.

Ting Zheng, Joelle BouSaba, Ann Taylor, Saam Dilmaghani, Irene Busciglio, Paula Carlson, Monique Torres, Michael Ryks, Duane Burton, William Scott Harmsen, Michael Camilleri

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023;21(13):3405-3414.e4

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Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis.

Mohamed-Eslam F Mohamed, David G Rizzo, Roberto Carcereri De Prati, Howard Sofen, Sasha Jazayeri, Wei Liu, Shashikanth Gannu, Shuai Hao, Gweneth F Levy, Ann Eldred, Laura K Ferris, Teresa Sligh, Ronilda D'Cunha, Yuli Qian

Clinical and translational science 2024;17(1):e13682

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Receptor conformation and constitutive activity in CCR5 chemokine receptor function and HIV infection.

Colleen A Flanagan

Advances in pharmacology (San Diego, Calif.) 2015;70():215-63

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Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.

Andreas R Muehler, Frank Fliegert, Hella Kohlhof, Marija Marolt, Irina Betscheider, Indika Leelasena, Thomas M Polasek, Daniel Vitt

Clinical pharmacology in drug development 2023;12(5):525-534

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Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Francisco Ciruela, Víctor Fernández-Dueñas, Jhonny Azuaje, Xavier Morató, Begoña Cordobilla, Joan Carles Domingo, Eddy Sotelo

Molecules (Basel, Switzerland) 2017;22(3):366

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Development and therapeutic potential of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists for autoimmune diseases.

Yonghui Wang, Nannan Sun, Lixue Lu

European journal of medicinal chemistry 2023;258():115574

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Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial.

Michel Lecendreux, Giuseppe Plazzi, Jean Charles Schwartz, Philippe Lehert, Jeanne Marie Lecomte, Isabelle Lecomte, Christian Caussé, Mikhail Poluektov, Patricia Franco, Gert Jan Lammers, Yves Dauvilliers

The Lancet. Neurology 2023;22(4):303-311

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Retinoic acid receptor modulators: a perspective on recent advances and promises.

William Bourguet, Susana Alvarez, Hinrich Gronemeyer, Angel R de Lera

Expert opinion on therapeutic patents 2011;21(1):55-63

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Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.

Taosheng Chen, Yan Lu, Sergio C Chai, Lei Yang, Wenwei Lin

European journal of medicinal chemistry 2016;108():505-528

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Ticagrelor inverse agonist activity at the P2Y receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate.

Michael Keith, Stuart J Mundell, Thomas Johnson, Khalid Naseem, James L Hutchinson, Sukhinder Bancroft, Matthew S Hindle, Kumuthu Amaradasa, Timothy Roberts, Tudor Dimofte, Jawad Khalil

British journal of pharmacology 2023;181(1):21-35

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Could the presence of sodium ion influence the accuracy and precision of the ligand-posing in the human A adenosine receptor orthosteric binding site using a molecular docking approach? Insights from Dockbench.

Stefano Moro, Enrico Margiotta, Giuseppe Deganutti

Journal of computer-aided molecular design 2019;32(12):1337-1346

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Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.

Christian Gege, Thomas Schlüter, Thomas Hoffmann

Bioorganic & medicinal chemistry letters 2015;24(22):5265-7

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In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.

Tomasz Wójcik, Marek Grosicki, Stefan Chlopicki, Katarzyna Kieć-Kononowicz

European journal of pharmacology 2016;777():49-59

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Results: 1 – 15 / 18

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Results for ""Drug Inverse Agonism""[mesh_terms]

Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.

Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance.

A Randomized, Controlled Trial of Efficacy and Safety of Cannabidiol in Idiopathic and Diabetic Gastroparesis.

Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis.

Receptor conformation and constitutive activity in CCR5 chemokine receptor function and HIV infection.

Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Development and therapeutic potential of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists for autoimmune diseases.

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial.

Retinoic acid receptor modulators: a perspective on recent advances and promises.

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.

Ticagrelor inverse agonist activity at the P2Y receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate.

Could the presence of sodium ion influence the accuracy and precision of the ligand-posing in the human A adenosine receptor orthosteric binding site using a molecular docking approach? Insights from Dockbench.

Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.

In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.

Results for
""Drug Inverse Agonism""[mesh_terms]