Caffeine and headaches.

R E Shapiro

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2007;28 Suppl 2():S179-83

PMID: 17508167

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Abstract

Caffeine is the most widely consumed psychostimulant drug. It is a potent antagonist of adenosine receptors at dosages consistent with common dietary intake. With infrequent exposure, caffeine may act as an analgesic for headache or an adjuvant for the actions of other analgesics. With chronic repetitive intake, caffeine is associated with an increased risk of development of analgesicoveruse headache, chronic daily headache and physical dependency. Cessation of caffeine use following chronic exposures leads to a withdrawal syndrome, with headache as a dominant symptom.

Address: University of Vermont, College of Medicine, Department of Neurology, Given C219B, 89 Beaumont Avenue, 05405 Burlington, VT, USA. [email protected]

DOI: 10.1007/s10072-007-0773-5

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MeSH Terms: Adenosine, Brain, Caffeine, Drug Combinations, Drug Synergism, Headache Disorders, Headache Disorders, Secondary, Humans, Purinergic P1 Receptor Agonists, Receptors, Purinergic P1, Substance Withdrawal Syndrome