Lubiprostone: a chloride channel activator.

Brian E Lacy, L Campbell Levy

Journal: Journal of clinical gastroenterology 2007;41(4):345-51

PMID: 17413599

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Abstract

In January 2006 the Food and Drug Administration approved lubiprostone for the treatment of chronic constipation in men and women aged 18 and over. Lubiprostone is categorized as a prostone, a bicyclic fatty acid metabolite of prostaglandin E1. Lubiprostone activates a specific chloride channel (ClC-2) in the gastrointestinal (GI) tract to enhance intestinal fluid secretion, which increases GI transit and improves symptoms of constipation. This article reviews the role of chloride channels in the GI tract, describes the structure, function, and pharmacokinetics of lubiprostone, and discusses clinically important data on this new medication.

Address: Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. [email protected]

DOI: 10.1097/01.mcg.0000225665.68920.df

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MeSH Terms: Alprostadil, Cathartics, Chloride Channels, Chlorides, Chronic Disease, Constipation, Fatty Acids, Female, Gastrointestinal Transit, Humans, Lubiprostone, Male