A pilot randomized controlled crossover study comparing regional heparinization to regional citrate anticoagulation for continuous venovenous hemofiltration.

R Bellomo, M Egi, I Baldwin, N Fealy, M Johnstone

Journal: The International journal of artificial organs 2007;30(4):301-7

PMID: 17520566

Abstract

OBJECTIVE

To evaluate the efficacy and safety of a regional heparinization and a regional citrate method of anticoagulation in CVVH.

DESIGN

Randomized controlled cross-over study.

SUBJECTS

Ten critically ill patients with acute renal failure.

SETTING

ICU of tertiary hospital.

INTERVENTION

CVVH was performed with pre-filter fluid replacement at 2000 ml/h and a blood flow rate of 150 ml/min. Regional heparinization was by the administration of heparin pre-filter at 1500 IU/h and protamine post-filter at 15 mg/h. Regional citrate anticoagulation was by means of a citrate-based replacement fluid (14 mmol/L) administered pre-dilution.

RESULTS

We studied nine males and one female. The mean age and APACHE II score were 70.5 and 17 respectively. Median circuit life was 13 hours (IQR 9.28) for the regional heparinization method compared to 17 hours (IQR 12,19.5) for the regional citrate method (p=0.77). There were no episodes of bleeding in either group.

CONCLUSION

Regional heparinization and regional citrate anticoagulation achieve similar circuit life in critically ill patients receiving CVVH.

Address: Department of Intensive Care, Austin Hospital, Melbourne - Australia.

DOI: 10.1177/039139880703000404

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MeSH Terms: Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Anticoagulants, Calcium, Citric Acid, Critical Care, Cross-Over Studies, Female, Hemodialysis Solutions, Hemofiltration, Heparin, Heparin Antagonists, Humans, Magnesium, Male, Middle Aged, Pilot Projects, Protamines, Safety, Time Factors, Treatment Outcome