The effects of superoxide dismutase on H2O2 formation.

Irwin Fridovich, Stefan I Liochev

Journal: Free radical biology & medicine 2007;42(10):1465-9

PMID: 17448892

Full Text on Elsevier Science View on PubMed

Abstract

Numerous reports of the effects of overproduction of SODs have been explained on the basis of increased H2O2 production by the catalyzed dismutation of O2-. In this review we consider the effects of increasing [SOD] on H2O2 formation and question this explanation.

Address: Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

DOI: 10.1016/j.freeradbiomed.2007.02.015

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MeSH Terms: Hydrogen Peroxide, Superoxide Dismutase