Methyl-CpG-binding domain proteins in plants: interpreters of DNA methylation.

Assaf Zemach, Gideon Grafi

Journal: Trends in plant science 2007;12(2):80-5

PMID: 17208509

Full Text on Elsevier Science View on PubMed

Abstract

The effect of DNA methylation on various aspects of plant cellular and developmental processes has been well documented over the past 35 years. However, the underlying molecular mechanism interpreting the methylation signal has only recently been explored with the isolation and characterization of the Arabidopsis methyl-CpG-binding domain (MBD) proteins. In this review, we highlight recent advances and present new models concerning Arabidopsis MBD proteins and their possible role in controlling chromatin structure mediated by CpG methylation.

Address: Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.

DOI: 10.1016/j.tplants.2006.12.004

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MeSH Terms: Amino Acid Motifs, Arabidopsis, Arabidopsis Proteins, Binding Sites, Chromatin Assembly and Disassembly, Conserved Sequence, DNA Methylation, DNA-Binding Proteins, Gene Silencing, Genes, rRNA, Models, Genetic