Calcium transport and sensing in TRPC channels - New insights into a complex feedback regulation.

Jasmin Baron, Klaus Groschner, Oleksandra Tiapko

Journal: Cell calcium 2023;116():102816

PMID: 37897981

Full Text on Elsevier Science View on PubMed

Abstract

Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory- and recently uncovered structural features, TRPC channels are considered to coordinate Ca and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.

Address: Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria.; Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria. Electronic address: [email protected].

DOI: 10.1016/j.ceca.2023.102816

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MeSH Terms: Calcium, Feedback, TRPC Cation Channels, Ion Transport, Calcium Channels