AMPK and metabolic disorders: The opposite roles of dietary bioactive components and food contaminants.

Ye Peng, Zexiu Qi, Yuqing Xu, Xueyan Yang, Yue Cui, Quancai Sun

Journal: Food chemistry 2023;437(Pt 1):137784

PMID: 37897819

Full Text on Elsevier Science View on PubMed

Abstract

AMPK is a key player in a variety of metabolic and physiological processes, which might be considered one of the most promising targets for both prevention and treatment of metabolic syndrome and its associated diseases. Many dietary components and contaminants have been recently demonstrated to prevent or promote the development these diseases via AMPK-mediated pathways. AMPK can be activated by diverse phytochemical substances such as EGCG, chicoric acid, tomatidine, and others, all of which have been found to contribute to preventing or ameliorating chronic disorders. On the other hand, recent studies have found that metabolic disruptions induced by pesticides such as 1,3-Dichloro-2-propanol, imidacloprid, permethrin, are attributed to the inactivation of AMPK. This review may contribute to the development of functional foods for treatment of metabolic syndrome and associated diseases through modulating AMPK pathway.

Address: Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China.; College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050018, China.; Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL 32306, United States. Electronic address: [email protected].

DOI: 10.1016/j.foodchem.2023.137784

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MeSH Terms: Humans, AMP-Activated Protein Kinases, Metabolic Syndrome, Metabolic Diseases, Diet, Food