Fecal elastase-1: utility in pancreatic function in cystic fibrosis.

James Heubi, Ameet Daftary, James Acton, Raouf Amin

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2006;5(2):71-6

PMID: 16603421

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Abstract

Early detection and management of pancreatic insufficiency is essential to optimize health and outcomes in cystic fibrosis patients. The gold standard measures for assessment of pancreatic function are direct pancreatic stimulation tests, which have numerous limitations. Estimation of fecal elastase-1 level to determine pancreatic function is an attractive alternative as the test is simple, rapid, cost-effective and easy to perform even in children. This review summarizes the data from studies reflecting the validity, limitation and advantages of fecal elastase-1 in assessing pancreatic function in cystic fibrosis patients.

Address: Department of Pulmonary Medicine and Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. [email protected]

DOI: 10.1016/j.jcf.2006.01.005

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MeSH Terms: Biomarkers, Carrier Proteins, Clinical Enzyme Tests, Cystic Fibrosis, Enzyme-Linked Immunosorbent Assay, Exocrine Pancreatic Insufficiency, Feces, Humans, Pancreatic Elastase, Reproducibility of Results, Sensitivity and Specificity