Effect of plant extracts on trans-sialidase activity in human blood plasma.

V V Kaplun, A N Orekhov, I A Sobenin, V V Tertov, D V Aksenov

Journal: Bulletin of experimental biology and medicine 2007;143(1):46-50

PMID: 18019010

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Abstract

We studied the effects of plant extracts and products of their biological treatment on trans-sialidase activity in human blood plasma. Extracts of kelp, fucus, yarrow, Saint John's wort, onion, and honey in vitro decreased trans-sialidase activity. Extracts of pollen (beebread) and garlic powder produced the maximum inhibitory effect. trans-Sialidase activity of blood plasma ex vivo decreased 2-fold after peroral administration of pollen and garlic powder. A correlation was found between the decrease in trans-sialidase activity in blood plasma and ability of blood plasma to induce cholesterol accumulation in cultured cells from the intact human aortic intima.

Address: Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, Moscow. [email protected]

DOI: 10.1007/s10517-007-0013-2

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MeSH Terms: Aorta, Cells, Cultured, Cholesterol, Eukaryota, Glycoproteins, Honey, Humans, Neuraminidase, Plant Extracts, Pollen, Tunica Intima