Comparative genome analyses of the pathogenic Yersiniae based on the genome sequence of Yersinia enterocolitica strain 8081.

Nicholas R Thomson, Sarah Howard, Brendan W Wren, Michael B Prentice

Journal: Advances in experimental medicine and biology 2007;603():2-16

PMID: 17966400

Abstract

This chapter represents a summary of the findings from the Yersinia enterocolitica strain 8081 whole genome sequence and the associated microarray analysis. Section 1 & 2 provide an introduction to the species and an overview of the general features of the genome. Section 3 identifies important regions within the genome which highlight important differences in gene function that separate the three pathogenic Yersinias. Section 4 describes genomic loci conferring important, species-specific, metabolic and virulence traits. Section 5 details extensive microarray data to provide an overview of species-specific core Y. enterocolitica gene functions and important insights into the intra-species differences between the high, low and non-pathogenic Y. enterocolitica biotypes.

Address: The Pathogen Sequencing Unit, Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Cambridge, UK. [email protected]

DOI: 10.1007/978-0-387-72124-8_1

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MeSH Terms: Cellulose, Chromosomes, Bacterial, CpG Islands, DNA, Bacterial, Evolution, Molecular, Genome, Bacterial, Methionine, Models, Genetic, Oligonucleotide Array Sequence Analysis, Operon, Phylogeny, Species Specificity, Virulence, Yersinia, Yersinia enterocolitica