Haemodynamic effects of intravenous quinaprilat in comparison to sodium nitroprusside in patients with chronic heart failure.

Stephan B Felix, Gert Baumann, Andrea Grohmann, Arne G Kieback

Journal: International journal of cardiology 2007;121(1):102-4

PMID: 17098309

Full Text on Elsevier Science View on PubMed

Abstract

We compared the haemodynamic effects of intravenous boluses of the ACE inhibitor quinaprilat with an intravenous infusion of sodium nitroprusside in 23 patients with chronic heart failure (NYHA Class III or IV). At the highest drug doses, sodium nitroprusside significantly increased stroke volume index (+6.63 ml/m(2), p=0.045), whereas quinaprilat induced only a minor increase (+1.79 ml/m(2), n.s.).

DOI: 10.1016/j.ijcard.2006.08.040

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MeSH Terms: Adolescent, Adult, Aged, Angiotensin-Converting Enzyme Inhibitors, Dose-Response Relationship, Drug, Heart Failure, Humans, Infusions, Intravenous, Middle Aged, Nitroprusside, Stroke Volume, Tetrahydroisoquinolines, Vasodilator Agents