Comparative analysis of efficiency and specificity of various sorbents for apheresis of low-density lipoproteins.

O I Afanas'eva, E V Altynova, A G Boldyrev, A A Sokolov, I Yu Adamova, S N Pokrovskii

Journal: Bulletin of experimental biology and medicine 2007;142(5):587-90

PMID: 17415469

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Abstract

Efficiency of sorbents for LDL apheresis was compared in vitro. The sorbents based on ion-exchange interaction of the ligand with LDL (Liposorber, DALI) exhibited minimum specificity towards the eliminated component, while immunosorbents (LNP-Lipopak, LDR-TheraSorb) were most efficient. By sorption capacity, the available hemosorbents are inferior to plasmasorbents, which explains low efficiency of the therapy based on single application of hemosorbents especially in patients with consederably increased content of LDL cholesterol.

Address: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health, Moscow.

DOI: 10.1007/s10517-006-0425-4

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MeSH Terms: Blood Component Removal, Humans, Immunosorbent Techniques, Lipoproteins, LDL