Interplay of lipid metabolism and inflammation in podocyte injury.

Zilv Luo, Zhaowei Chen, Jijia Hu, Guohua Ding

Journal: Metabolism: clinical and experimental 2023;150():155718

PMID: 37925142

Full Text on Elsevier Science View on PubMed

Abstract

Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and podocyte injury is a major cause of proteinuria in various primary and secondary glomerulopathies. Lipid dysmetabolism and inflammatory activation are the distinctive hallmarks of podocyte injury. Lipid accumulation and lipotoxicity trigger cytoskeletal rearrangement, insulin resistance, mitochondrial oxidative stress, and inflammation. Subsequently, inflammation promotes the progression of glomerulosclerosis and renal fibrosis via multiple pathways. These data suggest that lipid dysmetabolism positively or negatively regulates inflammation during podocyte injury. In this review, we summarize recent advances in the understanding of lipid metabolism and inflammation, and highlight the potential association between lipid metabolism and podocyte inflammation.

Address: Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Nephrology and Urology Research Institute of Wuhan University, Wuhan 430060, China.; Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Nephrology and Urology Research Institute of Wuhan University, Wuhan 430060, China. Electronic address: [email protected].; Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Nephrology and Urology Research Institute of Wuhan University, Wuhan 430060, China. Electronic address: [email protected].

DOI: 10.1016/j.metabol.2023.155718

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MeSH Terms: Humans, Lipid Metabolism, Podocytes, Proteinuria, Kidney Diseases, Inflammation, Lipids