Duplication, divergence and formation of novel protein topologies.

Veronica Morea, Christine Vogel

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(10):973-8

PMID: 16998824

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Abstract

The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.

Address: Institute for Cellular and Molecular Biology, University of Texas at Austin, TX, USA. [email protected]

DOI: 10.1002/bies.20474

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MeSH Terms: Amino Acid Motifs, Directed Molecular Evolution, Evolution, Molecular, Gene Duplication, Gene Fusion, Genetic Variation, Models, Genetic, Models, Molecular, Protein Structure, Secondary, Proteins, Sequence Deletion