Preservation solutions for solid organ transplantation.

C H Wilson, N R Brook, D Talbot

Journal: Mini reviews in medicinal chemistry 2006;6(10):1081-90

PMID: 17073708

Abstract

Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.

Address: The Liver/ Renal Unit, The Freeman Hospital, High Heaton, Newcastle-upon-Tyne, NE7 7DN, UK. [email protected]

DOI: 10.2174/138955706778560148

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MeSH Terms: Calcium, Colloids, Humans, Hydrogen-Ion Concentration, Organ Preservation Solutions, Organ Transplantation, Reactive Oxygen Species, Reperfusion Injury