A homology model of SERT based on the LeuT(Aa) template.

Ingebrigt Sylte, Aina Westrheim Ravna, Malgorzata Jaronczyk

Journal: Bioorganic & medicinal chemistry letters 2006;16(21):5594-7

PMID: 16919451

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Abstract

A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters from Aquifex aeolicus (LeuT(Aa)). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.

Address: Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

DOI: 10.1016/j.bmcl.2006.08.028

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MeSH Terms: Bacteria, Humans, Models, Molecular, Plasma Membrane Neurotransmitter Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Structural Homology, Protein