A new cyclotetrapeptide from marine fungus Trichoderma reesei.

Yi Sun, Li Tian, Yong-Fu Huang, Yi Sha, Yue-Hu Pei

Journal: Die Pharmazie 2006;61(9):809-10

PMID: 17020165

Abstract

A new cyclotetrapeptide, trichoderide A, was isolated from the marine fungus Trichoderma reesei. The structure was identified by spectral methods, and the stereochemical assignments were made by chiral HPLC of the hydrolyzed compound. Trichoderide A showed moderate cytotoxity against human A375-S2 melanoma cell line.

Address: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, PR China.

MeSH Terms: Amino Acids, Antineoplastic Agents, Cell Line, Tumor, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Drug Screening Assays, Antitumor, Humans, Hydrolysis, Magnetic Resonance Spectroscopy, Melanoma, Experimental, Peptides, Cyclic, Tetrazolium Salts, Thiazoles, Trichoderma