The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation.

P McGrogan, S F Ahmed, S C Wong, V E Macrae

Journal: Journal of pediatric gastroenterology and nutrition 2006;43(2):144-55

PMID: 16877976

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Abstract

Childhood inflammatory bowel disease (IBD) especially those with Crohn disease is commonly complicated by faltering growth and pubertal delay. Pro-inflammatory cytokines are often elevated in IBD and may affect linear growth and puberty either systemically or at the level of the growth plate. Further study of the underlying mechanisms of the deleterious effects of cytokines on the growth plate may improve management of faltering growth in childhood IBD. Well-controlled clinical studies of the respective effect of nutritional support, immunomodulatory therapy, biological agents and growth and puberty promoting agents on managing faltering growth also require further attention.

Address: Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow, UK.

DOI: 10.1097/01.mpg.0000226374.18494.14

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MeSH Terms: Adolescent, Body Height, Body Weight, Child, Child, Preschool, Cytokines, Female, Growth, Growth Disorders, Growth Hormone, Humans, Inflammatory Bowel Diseases, Male, Puberty, Delayed, Steroids