Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

Address: Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. [email protected].; Paris Cité University, Imagine Institute, Paris, France. [email protected].; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.; Paris Cité University, Imagine Institute, Paris, France.; Study Center for Immunodeficiencies, Necker Hospital for Sick Children, Paris, France.; Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, Darlinghurst, New South Wales, Australia.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Division of Pediatric Allergy and Immunology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.; Department of Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Virology, Cochin-Saint-Vincent de Paul Hospital, University of Paris, Paris, France.; Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Paris Cité University, Imagine Institute, INSERM UMR1163, Paris, France.; Section of Microbiology, University of Brescia, Brescia, Italy.; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Institute for Immunodeficiency, Center for Chronic Immunodeficiencies, Medical Center-University Hospital Freiburg, and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.; Division of Pediatric Clinical Immunology and Allergy, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey.; Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.; Department of Clinical Genetics, Uppsala University Hospital, Uppsala, Sweden.; Department of Immunology, Genetics and Pathology, Section of Clinical Genetics, Uppsala University and University Hospital, Uppsala, Sweden.; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.; Division of Immunology and Allergy, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.; The Canadian Centre for Primary Immunodeficiency and The Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency, The Hospital for Sick Children, Toronto, Ontario, Canada.; Immunology and Allergy, University of Western Sydney and Campbelltown Hospital, Campbelltown, New South Wales, Australia.; Division of Allergy and Immunology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.; Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Konya, Turkey.; Hospital de Niños Roberto del Río, Santiago, Chile.; Department of Pediatrics, Facultad de Medicina Clinica Alemana Universidad del Desarrollo, Santiago, Chile.; Laboratory of Lymphocyte Activation and Susceptibility to EBV, Paris Cité University, Imagine Institute, Inserm UMR1163, Paris, France.; Department of Anatomical Pathology, The Alfred Hospital, Prahran, Victoria, Australia.; Department of Clinical Immunology and Internal Medicine, National Reference Center for Autoimmune Diseases, Strasbourg University Hospital, Strasbourg, France.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Joint Unit Hospices Civils de Lyon-BioMérieux, Lyon, France.; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Immunology Division, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia.; Dept Medical Biology, University of Melbourne, Victoria, Parkville, Australia.; Dept Clinical Immunology and Allergy, The Royal Melbourne Hospital, Parkville, Australia.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Anna Children's Cancer Research Institute, Vienna, Austria.; Anna Children's Hospital, Vienna, Austria.; French National Reference Center for Primary Immunodeficiencies (CEREDIH), Necker-Enfants University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.; Department of Pediatric Immunology, Hematology and Rheumatology, Necker-Enfants Malades Hospital, AP-HP, Paris, France.; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia ASST-Spedali Civili di Brescia, Brescia, Italy.; Department of Immunology, Second Faculty of Medicine Charles University and Motol University Hospital, Prague, Czech Republic.; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.; Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle-upon-Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK.; Allergy and Clinical Immunology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Allergy and Immunology, Children's National Medical Center, Washington, DC, USA.; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.; Immunology and Allergy, Queensland Children's Hospital, South Brisbane, Queensland, Australia.; Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.; South Western Sydney Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; Department of Immunology, Allergy and HIV, St Vincent's Hospital, Sydney, New South Wales, Australia.; Centre for Cardiovascular Surgery and Transplantation, Medical Faculty, Masaryk University, Brno, Czech Republic.; Department of Paediatrics, Faculty of Medicine, Comenius University Bratislava, Bratislava, Slovakia.; Pediatric Department, E. Wolfson Medical Center, Tel Aviv University, Tel Aviv, Israel.; Pediatric Oncology Hematology Unit, University Hospital, Plurithématique CIC (CICP), Centre d'Investigation Clinique (CIC) 1401, Bordeaux, France.; Internal Medicine Department, Pitié-Salpêtrière Hospital, Paris, France.; Department of Internal Medicine & Infectious Diseases, Bordeaux Hospital University, Bordeaux, France.; Division of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.; Clinical Immunology Department, Saint Louis Hospital, Paris, France.; Department of Pediatric Hematology, Toulouse University Hospital, Toulouse, France.; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Pediatric Hematology, Oncology and Immunodeficiencies, University Children's Hospital Gießen, Giessen, Germany.; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.; Dr. Shahrooei Lab, Tehran, Iran.; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Allergy and Immunology, University of Medical Science, Antalya Education and Research Hospital, Antalya, Turkey.; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Immunology and Infectious Diseases, Sydney Children's Hospital Randwick, Western Sydney University, Campbelltown, New South Wales, Australia.; CNRS UMR 5308, ENS, UCBL, Lyon, France.; National Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE), Lyon, France.; Immunopathology Federation LIFE, Hospices Civils de Lyon, Lyon, France.; Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.; Centre d'Immunologie et des Maladies Infectieuses (CIMI), Sorbonne Université, INSERM U1135, Paris, France.; Department of Pediatrics and Public Health, Università degli Studi di Torino, Turin, Italy.; Internal Medicine, Clinical Immunology and Infectious Diseases Department, University Hospital Center, Reims, France.; IRMAIC EA 7509, URCA, Reims, France.; CHU Marseille, Hôpital La Timone, Service d'Hémato-oncologie Pédiatrique, Assistance Publique-Hôpitaux de Marseille, Marseille, France.; Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Department of Internal Medicine, Edouard Herriot Hospital, Lyon, France.; Department of Internal Medicine, Hôpital Michallon, CHU de Grenoble Alpes, Grenoble, France.; Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Departments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.; IRCCS Humanitas Research Hospital, Rozzano, Italy.; CNR-IRGB, Milan Unit, Milan, Italy.; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.; Paris Cité University, Paris, France.; Pediatric Radiology Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France.; CIRI (Centre International de Recherche en Infectiologie), Université de Lyon, Université Claude Bernard Lyon 1, INSERM U1111, CNRS, UMR5308, ENS Lyon, Université Jean Monnet de Saint-Etienne, Lyon, France.; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. [email protected].; Paris Cité University, Imagine Institute, Paris, France. [email protected].; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. [email protected].; Howard Hughes Medical Institute, New York, NY, USA. [email protected].; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France. [email protected].; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. [email protected].; Paris Cité University, Imagine Institute, Paris, France. [email protected].; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. [email protected].