Alpha-oxidation.

Ronald J A Wanders, Gerbert A Jansen

Journal: Biochimica et biophysica acta 2007;1763(12):1403-12

PMID: 16934890

Free Full Text on Elsevier Science View on PubMed

Abstract

Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched chain fatty acid, which is a constituent of the human diet. The presence of the 3-methyl group of phytanic acid prevents degradation by beta-oxidation. Instead, the terminal carboxyl group is first removed by alpha-oxidation. The mechanism of the alpha-oxidation pathway and the enzymes involved are described in this review.

Address: Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. [email protected]

DOI: 10.1016/j.bbamcr.2006.07.012

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MeSH Terms: Aldehydes, Dietary Fats, Fatty Acids, Humans, Oxidation-Reduction, Peroxisomes, Phytanic Acid, Stereoisomerism