Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis.

Ya-Jie Hu, Qian Lan, Bao-Jun Su, Yan Wang, Dong Liang

Journal: Fitoterapia 2024;172():105740

PMID: 37939734

Full Text on Elsevier Science View on PubMed

Abstract

Three new phenolic glycosides (1-3) and a new lignan glycoside (4), together with five known compounds (5-9) were isolated from the ethanol extract of the aerial part of Gaultheria leucocarpa var. yunnanensis (Franch.) T.Z.Hsu & R.C.Fang. Their structures were determined on the basis of spectroscopic techniques, experimental and calculated ECD spectra, acid hydrolysis, and enzymatic hydrolysis experiments. All the isolates were evaluated for their anti-inflammatory and antioxidant activities. Compounds 7 and 8 exhibited inhibitory effects against the LPS-induced production of NO with IC of 63.71 and 10.66 μM, respectively, compared to L-NMMA having an IC of 6.95 μM. Besides, compound 7 also represented significant DPPH radical scavenging activity with EC of 18.75 μM, comparable with vitamin C (EC = 15.77 μM).

Address: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: [email protected].; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2023.105740

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MeSH Terms: Glycosides, Lignans, Gaultheria, Molecular Structure, Anti-Inflammatory Agents, Cardiac Glycosides