Revolutionizing Tuberculosis Treatment: Uncovering New Drugs and Breakthrough Inhibitors to Combat Drug-Resistant .

Ankit Verma, Bindu Naik, Vijay Kumar, Sadhna Mishra, Megha Choudhary, Javed Masood Khan, Arun Kumar Gupta, Piyush Pandey, Sarvesh Rustagi, Barnali Kakati, Sanjay Gupta

Journal: ACS infectious diseases 2023;9(12):2369-2385

PMID: 37944023

Full Text on American Chemical Society View on PubMed

Abstract

Tuberculosis (TB) is a global health threat that causes significant mortality. This review explores chemotherapeutics that target essential processes in , such as DNA replication, protein synthesis, cell wall formation, energy metabolism, and proteolysis. We emphasize the need for new drugs to treat drug-resistant strains and shorten the treatment duration. Emerging targets and promising inhibitors were identified by examining the intricate biology of TB. This review provides an overview of recent developments in the search for anti-TB drugs with a focus on newly validated targets and inhibitors. We aimed to contribute to efforts to combat TB and improve therapeutic outcomes.

Address: Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, Uttarakhand, India.; Department of Food Science and Technology, Graphic Era Deemed to be University, Bell Road, Clement Town, Dehradun 248002, Uttarakhand, India.; Faculty of Agricultural Sciences, GLA University, Mathura 281406, UP, India.; Department of Food Science and Nutrition, Faculty of Food and Agricultural Sciences, King Saud University, 2460, Riyadh 11451, Saudi Arabia.; Department of Microbiology, Assam University, Silchur 788011, Assam, India.; Department of Food Technology, UCALS, Uttaranchal University, Dehradun 248007, Uttarakhand, India.; Department of Microbiology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248016, U.K., India.

DOI: 10.1021/acsinfecdis.3c00436

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https://doi.org/10.1021/acsinfecdis.3c00436

MeSH Terms: Humans, Mycobacterium tuberculosis, Tuberculosis, Antitubercular Agents, Tuberculosis, Multidrug-Resistant, DNA Replication