Targeting XBP-1 as a novel anti-cancer strategy.

Albert C Koong, Vibha Chauhan, Lorenzo Romero-Ramirez

Journal: Cancer biology & therapy 2006;5(7):756-9

PMID: 16861911

Abstract

The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

Address: Stanford University, Department of Radiation Oncology, CA 94305-5152, USA. [email protected]

DOI: 10.4161/cbt.5.7.2973

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MeSH Terms: DNA-Binding Proteins, Endoplasmic Reticulum, Humans, Hypoxia, Iron Regulatory Protein 1, Neoplasms, Protein Folding, Regulatory Factor X Transcription Factors, Transcription Factors, Up-Regulation, X-Box Binding Protein 1