Overview of protein glutathionylation.

Michael P Murphy, Aleksandra Filipovska

Journal: Current protocols in toxicology 2013;Chapter 6():Unit6.10

PMID: 23045136

Abstract

Many proteins contain free thiols that can be modified by the reversible formation of mixed disulfides with glutathione. Protein glutathionylation is of significance for defense against oxidative damage and in redox signaling. Here we outline the mechanisms and possible significance of protein glutathionylation.

Address: Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom.

DOI: 10.1002/0471140856.tx0610s28

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https://doi.org/10.1002/0471140856.tx0610s28

MeSH Terms: Glutaredoxins, Glutathione, Nitric Oxide, Oxidation-Reduction, Proteins, Sulfhydryl Compounds, Thioredoxins