Study on inactivation kinetics of hepatitis A virus and enteroviruses with peracetic acid and chlorine. New ICC/PCR method to assess disinfection effectiveness.

L Bigliardi, G Sansebastiano

Journal: Journal of preventive medicine and hygiene 2006;47(2):56-63

PMID: 17066904

Abstract

The virucidal activity of chlorine-compounds was studied using hepatitis A virus (HAV) and Poliovirus 2 and comparing the disinfectant efficiency of peracetic acid. HAV presented a higher resistance to HClO than Poliovirus did. With ClO2 the inactivation times of HAV were markedly shorter. A comparison between these data and those resulting from the kinetics with peracetic acid (PA) showed that PA is less effective than chlorine. As a preliminary to future research, the PCR-test integrated with cell-cultures was experimentally introduced for a quick evaluation of the HAV-infectiveness, with the aim of possible application in the field of disinfection and of viruses-isolation from environmental and food samples.

Address: Department of Public Health, Sec of Hygiene, University of Parma, Italy. [email protected]

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Cell Culture Techniques, Chlorine Compounds, Disinfectants, Dose-Response Relationship, Drug, Drug Resistance, Viral, Enterovirus B, Human, Hepatitis A virus, Hydrogen-Ion Concentration, Hypochlorous Acid, Linear Models, Logistic Models, Oxides, Peracetic Acid, Poliovirus, Polymerase Chain Reaction, Virus Inactivation