Transplantation: polyomavirus nephropathy and the risk of specific immunosuppression regimens.

Christine Wu, Parmjeet Randhawa, Jerry McCauley

Journal: TheScientificWorldJournal 2006;6():512-28

PMID: 16648908

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Abstract

BK virus is ubiquitously present in the latent state in humans, and awareness of the importance of BK polyomavirus is emerging among the kidney transplant community. First discovered in 1971 in the urine of a renal transplant recipient, BK virus nephropathy (BKVN) has come to be recognized as a significant cause of genitourinary disease and potential graft loss in the kidney transplant patient. In this review, we discuss the risk factors, available methods of diagnosis and therapeutic monitoring, and current approaches to therapy of BKVN.

Address: Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA. [email protected]

DOI: 10.1100/tsw.2006.93

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MeSH Terms: Algorithms, Antibodies, Viral, Antiviral Agents, BK Virus, Biopsy, DNA, Viral, Diagnosis, Differential, Humans, Immunosuppressive Agents, Kidney Transplantation, Nephritis, Interstitial, Polymerase Chain Reaction, Polyomavirus Infections, Postoperative Complications, Risk Factors, Tumor Virus Infections, Urine, Viral Load