Epidermodysplasia verruciformis and generalized verrucosis: the same disease?

T Yanagi, A Shibaki, Y Tsuji-Abe, K Yokota, H Shimizu

Journal: Clinical and experimental dermatology 2006;31(3):390-3

PMID: 16681585

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Abstract

We report a patient with epidermodysplasia verruciformis (EV) who had severe generalized verrucous skin lesions for 50 years without any immunological abnormality. Microscopic examination showed two histopathological features, including seborrhoeic keratosis and common warts. The detected human papilloma virus (HPV) types were found to be HPV 3, 50, 5, and 76, using a degenerate PCR method. EV and generalized verrucosis are distinguished by slight differences in clinical symptoms or HPV types, so there should be no apparent differential points common to both diseases. Therefore, we propose that an abnormal susceptibility specific to HPV, which is the most characteristic feature in EV, should be regarded as a differential point in these two diseases.

Address: Department of Dermatology, Hokkaido University Graduate School of Medicine, Japan. [email protected]

DOI: 10.1111/j.1365-2230.2006.02100.x

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MeSH Terms: Antiviral Agents, Calcitriol, DNA, Viral, Epidermodysplasia Verruciformis, Etretinate, Foot Dermatoses, Humans, Immunocompetence, Leg Dermatoses, Male, Middle Aged, Papillomaviridae, Papillomavirus Infections, Polymerase Chain Reaction, Warts