Novel anti-viral therapy: drugs that block HIV entry at different target sites.

Sandra Siegert, Peter Schnierle, Barbara S Schnierle

Journal: Mini reviews in medicinal chemistry 2006;6(5):557-62

PMID: 16719830

Abstract

Drugs that block the entry of human immunodeficiency virus type 1 (HIV-1) into host cells abrogate the establishment of a productive infection and should ideally diminish the chances of HIV-1 developing resistance. This review will give an overview of the mechanism by which the envelope glycoprotein mediates HIV-1 entry and will summarize current drug developments.

Address: Department of Virology, Paul-Ehrlich-Institut, Paul-Ehrlich Strasse 51-59, 63225 Langen, Germany.

DOI: 10.2174/138955706776876267

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MeSH Terms: Amino Acid Sequence, CCR5 Receptor Antagonists, Cells, Cultured, HIV, HIV Fusion Inhibitors, Humans, Molecular Sequence Data, Receptors, CXCR4