Monogenic Etiology of Hypertension.

Vaishali Singh, Scott K Van Why

Journal: The Medical clinics of North America 2023;108(1):157-172

PMID: 37951648

Full Text on Elsevier Science View on PubMed

Abstract

Monogenic hypertension encompasses a group of conditions wherein single gene mutations result in increased renal sodium reabsorption manifesting as low renin hypertension. As these diseases are rare, their contribution to hypertension in children and adolescents is often overlooked. Precise diagnosis is essential in those who have not been found to have more common identifiable causes of hypertension in adolescents, since treatment strategies for these rare conditions are specific and different from antihypertensive regimens for the other more common causes of hypertension in this age group. The objective of this review is to provide insight to the rare, monogenic forms of hypertension.

Address: Department of Pediatrics, Medical College of Wisconsin, Suite 510, 999 North 92nd Street, Milwaukee, WI 53226, USA. Electronic address: [email protected].; Department of Pediatrics, Medical College of Wisconsin, Suite 510, 999 North 92nd Street, Milwaukee, WI 53226, USA.

DOI: 10.1016/j.mcna.2023.06.005

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MeSH Terms: Child, Adolescent, Humans, Hypertension, Mutation, Causality