Inflammation, brain damage and visual dysfunction in preterm infants.

Olaf Dammann, Alan Leviton

Journal: Seminars in fetal & neonatal medicine 2007;11(5):363-8

PMID: 16581321

Full Text on Elsevier Science View on PubMed

Abstract

Antenatal intrauterine infection and the fetal inflammatory response appear to be important pathogenetic factors in preterm birth and subsequent neonatal disorders of the lung and brain. In this paper, we expand this concept to include visual dysfunction. Although present data tend to support our notion, we suggest that more experimental and epidemiological research is needed to elucidate mechanisms of infection/inflammation-induced damage to the eye and visual brain pathways of preterm infants.

Address: Perinatal Infectious Disease Epidemiology Unit, Department of Gynecology, Hannover Medical School, OE 6415, 30623 Hannover, Germany. [email protected]

DOI: 10.1016/j.siny.2006.02.003

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MeSH Terms: Brain Injuries, Chorioamnionitis, Female, Fetal Diseases, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Inflammation, Pregnancy, Premature Birth, Retinopathy of Prematurity, Vision Disorders