Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.

João M Anghinoni, Paloma T Birmann, Marcia J da Rocha, Caroline S Gomes, Michael J Davies, César A Brüning, Lucielli Savegnago, Eder J Lenardão

Journal: Molecules (Basel, Switzerland) 2023;28(21):7349

PMID: 37959771

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Abstract

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

Address: Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.; Neurobiotechnology Research Group (GPN), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Building 12.6, Blegdamsvej 3, 2200 Copenhagen, Denmark.

DOI: 10.3390/molecules28217349

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MeSH Terms: Antioxidants, Selenium, Oxidative Stress, Glutathione Peroxidase, Trace Elements, Organoselenium Compounds, Thioredoxin-Disulfide Reductase