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Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population.

M Ivković, V Ranković, A Tarasjev, S Orolicki, A Damjanović, V R Paunović, S Romac

Journal: The International journal of neuroscience 2006;116(2):157-64

PMID: 16393881

Full Text on Atypon View on PubMed

Abstract

KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.

Address: Institute for Psychiatry, Clinical Center of Serbia, Belgrade, Serbia and Montenegro.
DOI: 10.1080/00207450341514

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MeSH Terms: Adolescent, Adult, Analysis of Variance, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Genetic, Reference Values, Schizophrenia, Small-Conductance Calcium-Activated Potassium Channels, Statistics, Nonparametric, Trinucleotide Repeats, Yugoslavia
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