Pathogens reWritE Rho's rules.

Richard D Hayward, Vassilis Koronakis

Journal: Cell 2006;124(1):15-7

PMID: 16413475

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Abstract

Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.

Address: University of Cambridge, Department of Pathology, Cambridge CB2 1QP, UK.

DOI: 10.1016/j.cell.2005.12.024

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MeSH Terms: Amino Acid Motifs, Bacteria, Bacterial Proteins, Humans, Molecular Mimicry, Signal Transduction, Virulence, ras Proteins