Influence of early postnatal nutritional management on oxidative stress and antioxidant defence in extreme prematurity.

Melinda Y Yeung

Journal: Acta paediatrica (Oslo, Norway : 1992) 2006;95(2):153-63

PMID: 16449020

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Abstract

UNLABELLED

The increased survival of infants born at mid-gestation in the last decade is associated with significant oxygen free radical-mediated morbidities. Resuscitation with 100% oxygen, oxidant load from parenteral nutrition fluids, and oxidant stress inherent to the systemic inflammatory state subsequent to infection and tissue injury are all contributory.

CONCLUSION

Improving early postnatal protein nutrition and the formulation of parenteral nutrition fluids would potentially reduce the oxidative stress and enhance the antioxidant defence of extremely premature newborns.

Address: Department of Pharmacy, The Children's Hospital at Westmead, New South Wales, Australia. [email protected]

DOI: 10.1080/08035250500301133

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MeSH Terms: Age Factors, Antioxidants, Brain, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Intensive Care, Neonatal, Lipid Peroxidation, Oxidative Stress, Parenteral Nutrition