Sesquiterpenoids and bibenzyl derivative from Dendrobium hercoglossum.

Hui-Qin Chen, Dong-Sheng Guo, Hao Wang, Cai-Hong Cai, Jing-Zhe Yuan, Hao-Fu Dai, Li Yang, Wen-Li Mei

Journal: Fitoterapia 2024;172():105748

PMID: 37967770

Full Text on Elsevier Science View on PubMed

Abstract

Three new sesquiterpenoids, dendrohercoglin A - C (1-3), and one new bibenzyl derivative, dendronbiline D (4), together with nine known sesquiterpenoids (5-13) were isolated from Dendrobium hercoglossum. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and ECD calculations. All the compounds were evaluated for their neuroprotective and anti-inflammatory activities. Compounds 2 and 3 increased the HO-damaged SH-SY5Y cell viabilities from 43.3% to 58.6% and 68.4%, respectively. Compound 4 exhibited pronounced anti-inflammatory activity with IC value of 9.5 ± 0.45 μM which was superior to the reference compound quercetin (IC: 15.7 ± 0.89 μM).

Address: National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China.; Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Experimental Center of Tropical Forestry, Chinese Academy of Forestry/Guangxi Youviquan Forest Ecosvstem Research Station, Pingxiang, Guangxi, 532600, China.; National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China. Electronic address: [email protected].; National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China. Electronic address: [email protected].; National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2023.105748

Link outs

Free resources

Medical:

https://medlineplus.gov/neuroblastoma.html

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0367...

MeSH Terms: Humans, Dendrobium, Molecular Structure, Hydrogen Peroxide, Neuroblastoma, Magnetic Resonance Spectroscopy, Sesquiterpenes, Bibenzyls, Anti-Inflammatory Agents