Chutes and Ladders: the search for protein kinases that act on AMPK.

Lee A Witters, Bruce E Kemp, Anthony R Means

Journal: Trends in biochemical sciences 2006;31(1):13-6

PMID: 16356723

Full Text on Elsevier Science View on PubMed

Abstract

AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis in mammalian cells, is, in turn, regulated by long-sought upstream protein kinases (AMPKKs). Following the recent identification of the tumor-suppressor kinase LKB1 as an AMPKK, a broader role for AMPK in metabolic economy has been unveiled by a new body of work from three groups that implicates the Ca(2+)/calmodulin-dependent protein kinase kinases as AMPKKs. We suggest that PKE (protein kinase "energy" or "economy") is now an apt name for this kinase, which regulates both cellular and whole-organism energy homeostasis.

Address: Departments of Medicine and Biochemistry, Dartmouth Medical School and the Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. [email protected]

DOI: 10.1016/j.tibs.2005.11.009

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MeSH Terms: AMP-Activated Protein Kinase Kinases, AMP-Activated Protein Kinases, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Energy Metabolism, Homeostasis, Models, Biological, Models, Molecular, Multienzyme Complexes, Protein Conformation, Protein Kinases, Protein Serine-Threonine Kinases