A simplified approach to understanding urea kinetics in peritoneal dialysis and hemodialysis.

Madhukar Misra, Karl Nolph

Journal: Contributions to nephrology 2006;150():20-27

PMID: 16720987

Full Text on S. Karger AG, Basel, Switzerland View on PubMed

Abstract

Urea, a small molecular solute, is the candidate molecule commonly used to understand solute kinetics both in peritoneal dialysis and hemodialysis. Serum urea or serum urea nitrogen levels are utilized to calculate measures of dialysis adequacy and nutritional status in dialysis patients. The kinetic behavior of this molecule is however different for a continuous therapy like peritoneal dialysis vis a vis an intermittent therapy like hemodialysis. This article presents a simplified approach to understanding urea kinetics on dialysis.

Address: Department of Medicine, Division of Nephrology, University of Missouri Columbia, Columbia, Mo., USA.

DOI: 10.1159/000093444

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MeSH Terms: Blood Urea Nitrogen, Humans, Kidney, Metabolic Clearance Rate, Peritoneal Dialysis, Renal Dialysis, Urea