Exploring the utility of FTS as a bonafide binding partner for EGFR: A potential drug target for cervical cancer.

Sneha Krishnamoorthy, Bharathi Muruganantham, Jae-Ran Yu, Woo-Yoon Park, Sridhar Muthusami

Journal: Computers in biology and medicine 2023;167():107592

PMID: 37976824

Full Text on Elsevier Science View on PubMed

Abstract

Establishment of human papilloma virus (HPV) infection and its progression to cervical cancer (CC) requires the participation of epidermal growth factor (EGF) receptor (EGFR) and fused toes homolog (FTS). This review is an attempt to understand the structure-function relationship between FTS and EGFR as a tool for the development of newer CC drugs. Motif analysis was performed using national center for biotechnology information (NCBI), kyoto encyclopedia of genes and genomes (KEGG), simple modular architecture research tool (SMART) and multiple expectation maximizations for motif elicitation (MEME) database. The secondary and tertiary structure prediction of FTS was performed using DISOPRED3 and threading assembly, respectively. A positive correlation was found between the transcript levels of FTS and EGFR. Amino acids responsible for interaction between EGFR and FTS were determined. The nine micro-RNAs (miRNAs) that regulates the expression of FTS were predicted using Network Analyst 3.0 database. hsa-miR-629-5p and hsa-miR-615-3p are identified as significant positive and negative regulators of FTS gene expression. This review opens up new avenues for the development of CC drugs which interfere with the interaction between FTS and EGFR.

Address: Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India.; Centre for Cancer Research, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India.; Department of Environmental and Tropical Medicine, Konkuk University College of Medicine, Chungju, South Korea.; Department of Radiation Oncology Hospital, College of Medicine, Chungbuk National University, Cheongju, South Korea. Electronic address: [email protected].; Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India; Centre for Cancer Research, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India. Electronic address: [email protected].

DOI: 10.1016/j.compbiomed.2023.107592